All Issues

Vol.10, 2020
Vol.9, 2019
Vol.8, 2018
Vol.7, 2017
Vol.6, 2016
Vol.5, 2015
Vol.4, 2014
Vol.3, 2013
Vol.2, 2012
Vol.1, 2011
Volume 10, Number 2, 2020, Pages 667-685                                                                DOI:10.11948/20190081
Analysis of an HIV model with post-treatment control
Shaoli Wang,Fei Xu
Keywords:HIV infection, mathematical model, bistable behavior, post-treatment immune control, elite control.
      Recent investigation indicated that latent reservoir and immune impairment are responsible for the post-treatment control of HIV infection. In this paper, we simplify the disease model with latent reservoir and immune impairment and perform a series of mathematical analysis. We obtain the basic infection reproductive number $R_{0}$ to characterize the viral dynamics. We prove that when $R_{0}<1$, the uninfected equilibrium of the proposed model is globally asymptotically stable. When $R_{0}>1$, we obtain two thresholds, the post-treatment immune control threshold and the elite control threshold. The model has bistable behaviors in the interval between the two thresholds. If the proliferation rate of CTLs is less than the post-treatment immune control threshold, the model does not have positive equilibria. In this case, the immune free equilibrium is stable and the system will have virus rebound. On the other hand, when the proliferation rate of CTLs is greater than the elite control threshold, the system has stable positive immune equilibrium and unstable immune free equilibrium. Thus, the system is under elite control.
PDF      Download reader