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 Volume 6, Number 1, 2016, Pages 12-29                                                                DOI：10.11948/2016002 Network science faces the challenge and opportunity:exploring Network of Networks" and its unified theoretical framework Jin-Qing Fang,Quan-Hui Liu,Ming Tang,Qiang Liu,Yong Li Keywords:Network of networks; challenges and opportunities; multilayer coupled networks; spreading dynamics. Abstract: In the era of big data, network science is facing new challenges and opportunities. This review article focuses on discussing one of the hottest subjects of network science - network of networks" (NON). The main features, several typical examples and the main progress for NON are outlined, including the epidemic spreading in multilayer coupled networks. Finally the most challenging tasks for NON are proposed. PDF      Download reader